Here's a bit of a pharmacokinetic puzzle posed by a nurse, and the more I think about it, the more interested I am in the possible answer. The question was simply, "what would happ …

What is the best technique for confirming adequate depth of anesthesia immediately before insertion of a laryngeal mask? I am not referring to confirming the induction of anesthes …

The rep for a competing formulation of propofol has just left. He wishes us to embrace his formulation of propofol, claiming a reduction of pain on injection from 60% to 38% but at …

Here's one for the history and trivia buffs: how was propofol first formulated? For extra points, when and where was the research conducted that investigated how to formulate prop …

I usually add 2 mL of 1% lignocaine to propofol (20 mL of 1% propofol) but despite this I still observe a fairly high proportion of patients finding the injection uncomfortable - m …